NYMC Faculty Publications

Document Type

Article

Publication Date

3-3-2016

Department

Medicine

Abstract

Cyclin D1 (CCND1) protein overexpression and/or the t(11;14)(q13;q32) translocation are the pathognomonic hallmarks of mantle cell lymphoma (MCL). However, there have been cases that lacked both t(11;14) and cyclin D1 protein but still had a gene expression profile suggesting a diagnosis of MCL. SOX11 expression was detected in most cyclin D1- negative MCL and can serve as a specific biomarker for the diagnosis of this subset of MCL. Lack of SOX11 expression in MCL was associated with an indolent subset and favorable prognosis.

Publisher's Statement

Originally published in Biomarker Research. Licensed under CC-BY 4.0. https://doi.org/10.1186/s40364-016-0060-9

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