NYMC Faculty Publications

Document Type

Article

Publication Date

3-24-2016

Department

Medicine

Second Department

Pathology

Abstract

The V617F mutation of Janus-associated kinase 2 (JAK2) is commonly seen in myeloproliferative neoplasms (MPN). Transformation of JAK2 positive MPNs to acute leukemia has been reported. We here report a case of acute promyelocytic leukemia which was later confirmed to have a co-existing JAK2 V617F positive MPN. In addition, the patient was found to have FLT3-TKD mutation, which, together with PML/RARa, could play a role in the MPN transformation to APL.

Publisher's Statement

Originally published in Stem Cell Investigation. Licensed under CC-BY 4.0. https://doi.org/10.21037/sci.2016.03.02

Share

COinS