Acute Promyelocytic Leukemia Co-Existing with JAK2 V617F Positive Myeloproliferative Neoplasm: A Case Report

Authors

Aleksandra Mamorska-Dyga, New York Medical College
Jingjing Wu
Pallavi Khattar, New York Medical CollegeFollow
Faisal Ronny, New York Medical College
Humayun Islam, New York Medical CollegeFollow
Karen Seiter, New York Medical CollegeFollow
Delong Liu, New York Medical CollegeFollow

First Page

8

Last Page

8

Document Type

Article

Publication Date

3-24-2016

Department

Medicine

Second Department

Pathology, Microbiology and Immunology

Abstract

The V617F mutation of Janus-associated kinase 2 (JAK2) is commonly seen in myeloproliferative neoplasms (MPN). Transformation of JAK2 positive MPNs to acute leukemia has been reported. We here report a case of acute promyelocytic leukemia which was later confirmed to have a co-existing JAK2 V617F positive MPN. In addition, the patient was found to have FLT3-TKD mutation, which, together with PML/RARa, could play a role in the MPN transformation to APL.

Recommended Citation

Mamorska-Dyga, A., Wu, J., Khattar, P., Ronny, F. M., Islam, H., Seiter, K., & Liu, D. (2016). Acute promyelocytic leukemia co-existing with JAK2 V617F positive myeloproliferative neoplasm: A case report. Stem Cell Investigation, 3, 8. doi:10.21037/sci.2016.03.02

Publisher's Statement

Originally published in Stem Cell Investigation. Licensed under CC-BY 4.0. https://doi.org/10.21037/sci.2016.03.02