Critical Evaluation of the Changes in Glutamine Synthetase Activity in Models of Cerebral Stroke

Authors

Thomas M. Jeitner, New York Medical CollegeFollow
Kevin Battaile
Arthur J L Cooper, New York Medical CollegeFollow

First Page

2544

Last Page

2556

Document Type

Article

Publication Date

12-1-2015

Department

Biochemistry and Molecular Biology

Abstract

The following article addresses some seemingly paradoxical observations concerning cerebral glutamine synthetase in ischemia-reperfusion injury. In the brain, this enzyme is predominantly found in astrocytes and catalyzes part of the glutamine-glutamate cycle. Glutamine synthetase is also thought to be especially sensitive to inactivation by the oxygen- and nitrogen-centered radicals generated during strokes. Despite this apparent sensitivity, glutamine synthetase specific activity is elevated in the affected tissues during reperfusion. Given the central role of the glutamine-glutamate cycle in the brain, we sought to resolve these conflicting observations with the view of providing an alternative perspective for therapeutic intervention in stroke.

Recommended Citation

Jeitner, T. M., Battaile, K., & Cooper, A. J. (2015). Critical evaluation of the changes in glutamine synthetase activity in models of cerebral stroke. Neurochemical Research, 40(12), 2544-2556. doi:10.1007/s11064-015-1667-1

Publisher's Statement

Originally published in Neurochemical Research. https://doi.org/10.1007/s11064-015-1667-1