Cyclin D1 (CCND1) protein overexpression and/or the t(11;14)(q13;q32) translocation are the pathognomonic hallmarks of mantle cell lymphoma (MCL). However, there have been cases that lacked both t(11;14) and cyclin D1 protein but still had a gene expression profile suggesting a diagnosis of MCL. SOX11 expression was detected in most cyclin D1- negative MCL and can serve as a specific biomarker for the diagnosis of this subset of MCL. Lack of SOX11 expression in MCL was associated with an indolent subset and favorable prognosis.
Narurkar, R., Alkayem, M., & Liu, D. (2016). SOX11 is a biomarker for cyclin D1-negative mantle cell lymphoma. Biomarker Rsearch, 4, 6. doi:10.1186/s40364-016-0060-9