Mast cell activation syndrome (MCAS) is a disorder in which patients experience symptoms and signs attributable to inappropriate mast cell activation and mediator release. Multiorgan involvement in patients can result in significant morbidity and possible mortality. Limited literature exists regarding anesthetic management of patients with MCAS. We report a case of vaginal delivery with neuraxial labor analgesia in a parturient with this condition and highlight the importance of multidisciplinary planning for uneventful outcomes. Stress can trigger life-threatening symptoms, and counseling is important to allay patients' fears. Optimum medical control, adequate premedication, avoidance of triggers, and preparedness to treat serious mediator effects are key. We review MCAS and discuss anesthetic considerations for patients with this mast cell disorder.
Kumaraswami, S., & Farkas, G. (2018). Management of a Parturient with Mast Cell Activation Syndrome: An Anesthesiologist's Experience. Case Reports in Anesthesiology, 2018, Art. ID.: 8920921-5 pages. https://doi.org/10.1155/2018/8920921
Originally published in Case Reports in Anesthesiology, 2018 [Article 8920921]. The original material can be found here.
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