Benefits and Challenges With Diagnosing Chronic and Late Acute GVHD in Children Using the NIH Consensus Criteria

Authors

Geoffrey Cuvelier
Eneida R. Nemecek
Justin T. Wahlstrom
Carrie L. Kitko
Victor A. Lewis
Tal Schechter
David A. Jacobsohn
Andrew C. Harris
Michael A. Pulsipher
Henrique Bittencourt
Allyson Flower, New York Medical CollegeFollow
Kirk R. Schultz

Journal Title

Blood

First Page

304

Last Page

316

Document Type

Article

Publication Date

July 2019

Department

Pediatrics

Abstract

Chronic graft-versus-host disease (cGVHD) and late acute graft-versus-host disease (L-aGVHD) are understudied complications of allogeneic hematopoietic stem cell transplantation in children. The National Institutes of Health Consensus Criteria (NIH-CC) were designed to improve the diagnostic accuracy of cGVHD and to better classify graft-versus-host disease (GVHD) syndromes but have not been validated in patients /=12 years of age being at risk for cGVHD. Applying the NIH-CC in pediatrics is feasible and reliable; however, further refinement of the criteria specifically for children is needed.

Comments

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Recommended Citation

Cuvelier, G., Nemecek, E., Wahlstrom, J., Kitko, C., Lewis, V., Schechter, T., Jacobsohn, D., Harris, A., Pulsipher, M., Bittencourt, H., Flower, A., & Schultz, K. (2019). Benefits and Challenges With Diagnosing Chronic and Late Acute GVHD in Children Using the NIH Consensus Criteria. Blood, 134 (3), 304-316. https://doi.org/10.1182/blood.2019000216