Benefits and Challenges With Diagnosing Chronic and Late Acute GVHD in Children Using the NIH Consensus Criteria
Chronic graft-versus-host disease (cGVHD) and late acute graft-versus-host disease (L-aGVHD) are understudied complications of allogeneic hematopoietic stem cell transplantation in children. The National Institutes of Health Consensus Criteria (NIH-CC) were designed to improve the diagnostic accuracy of cGVHD and to better classify graft-versus-host disease (GVHD) syndromes but have not been validated in patients /=12 years of age being at risk for cGVHD. Applying the NIH-CC in pediatrics is feasible and reliable; however, further refinement of the criteria specifically for children is needed.
Cuvelier, G., Nemecek, E., Wahlstrom, J., Kitko, C., Lewis, V., Schechter, T., Jacobsohn, D., Harris, A., Pulsipher, M., Bittencourt, H., Flower, A., & Schultz, K. (2019). Benefits and Challenges With Diagnosing Chronic and Late Acute GVHD in Children Using the NIH Consensus Criteria. Blood, 134 (3), 304-316. https://doi.org/10.1182/blood.2019000216