NYMC Faculty Publications

Title

Synthetically Modified Methoxsalen for Enhanced Cytotoxicity in Light and Dark Reactions

First Page

619

Last Page

622

Document Type

Article

Publication Date

2-1-2019

Department

Environmental Health Science

Abstract

Linear furocoumarins, also known as psoralens, are clinically useful photo-activated pharmaceuticals employed to address hyperproliferative skin diseases. Seven diverse cytotoxic pharmacophores have been synthetically attached to 8-methoxypsoralen via a 5-amino functionality. The resulting unique set of compounds was evaluated for dark and light toxicity against PAM212 keratinocytes in culture.

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