Synthetically Modified Methoxsalen for Enhanced Cytotoxicity in Light and Dark Reactions
Environmental Health Science
Linear furocoumarins, also known as psoralens, are clinically useful photo-activated pharmaceuticals employed to address hyperproliferative skin diseases. Seven diverse cytotoxic pharmacophores have been synthetically attached to 8-methoxypsoralen via a 5-amino functionality. The resulting unique set of compounds was evaluated for dark and light toxicity against PAM212 keratinocytes in culture.
Guillon, C., Jan, Y., Foster, N., Ressner, J., Heck, D., Laskin, J., & Heindel, N. (2019). Synthetically Modified Methoxsalen for Enhanced Cytotoxicity in Light and Dark Reactions. Bioorganic & Medicinal Chemistry Letters, 29 (4), 619-622. https://doi.org/10.1016/j.bmcl.2018.12.048