NYMC Faculty Publications

Title

Synthetically Modified Methoxsalen for Enhanced Cytotoxicity in Light and Dark Reactions

Document Type

Article

Publication Date

February 2019

Department

Environmental Health Science

Abstract

Linear furocoumarins, also known as psoralens, are clinically useful photo-activated pharmaceuticals employed to address hyperproliferative skin diseases. Seven diverse cytotoxic pharmacophores have been synthetically attached to 8-methoxypsoralen via a 5-amino functionality. The resulting unique set of compounds was evaluated for dark and light toxicity against PAM212 keratinocytes in culture.

Share

COinS