NYMC Faculty Publications

Title

Similar Neurocognitive Outcomes After 48 Weeks in HIV-1-Infected Participants Randomized to Continue Tenofovir/Emtricitabine + Atazanavir/Ritonavir or Simplify to Abacavir/Llamivudine + Atazanavir

Document Type

Article

Publication Date

February 2019

Department

Medicine

Abstract

Human immunodeficiency virus (HIV)-associated neurocognitive disorders can persist in many patients despite achieving viral suppression while on antiretroviral therapy (ART). Neurocognitive function over 48 weeks was evaluated using a Cogstate test battery assessing psychomotor function, attention, learning, and working memory in 293 HIV-1-infected, ART-experienced, and virologically suppressed adults. The ASSURE study randomized participants 1:2 to remain on tenofovir/emtricitabine (TDF/FTC) and ritonavir-boosted atazanavir (ATV/r) or simplify to abacavir/lamivudine + atazanavir (ABC/3TC + ATV). Neurocognitive z-scores were computed using demographically adjusted normative data and were classified as "impaired" (defined as either a z-score

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