Intrahepatic Upregulation of MRTF-A Signaling Contributes to Increased Hepatic Vascular Resistance in Cirrhotic Rats With Portal Hypertension
BACKGROUND: Portal hypertension in cirrhosis is mediated, in part, by increased intrahepatic resistance, reflecting massive structural changes associated with fibrosis and intrahepatic vasoconstriction. Activation of the Rho/MRTF/SRF signaling pathway is essential for the cellular regulatory network of fibrogenesis. The aim of this study was to investigate MRTF-A-mediated regulation of intrahepatic fibrogenesis in cirrhotic rats.
METHODS: Portal hypertension was induced in rats via an injection of CCl
RESULTS: Upregulation of MRTF-A protein expression in the livers of rats with CCl
CONCLUSION: Increased intrahepatic resistance in rats with CCl
Zheng, L., Qin, J., Sun, L., Gui, L., Huang, A., Sun, D., & Luo, M. (2017). Intrahepatic Upregulation of MRTF-A Signaling Contributes to Increased Hepatic Vascular Resistance in Cirrhotic Rats With Portal Hypertension. Clinics and Research in Hepatology and Gastroenterology, 41 (3), 303-310. https://doi.org/10.1016/j.clinre.2016.11.010
Originally published in Clinics and Research in Hepatology and Gastroenterology, 41 (3), 303-310. The original material can be found here.