NYMC Faculty Publications

Title

Chronic Myelomonocytic Leukemia as a Transformation from Polycythemia Vera

First Page

14

Last Page

16

Document Type

Article

Publication Date

3-14-2019

Department

Medicine

Abstract

The hallmark of Polycythemia vera (PV) is the presence of JAK2(V617F) mutation and increased RBC mass. Chronic myelomonocytic leukemia (CMML) is defined as persistent blood absolute monocyte count (AMC) >/= 1x10(9)/L for at least 3 months with myeloid cell dysplasia. Few cases of evolved CMML from PV have been described. We present a case of PV that progressed to CMML. We demonstrated the CMML clone was most likely derived from PV- JAK2(V617F) clone. This clone carried a complex genetic mutations of ASXL1, RUNX1, SRSF2 and TET2, NRAS, KRAS, plus CMML cells were of the classical phenotype CD14(+) CD16(-)by flow cytometry.

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