Cardiac Resynchronization Therapy for Heart Failure
Cardiac resynchronization therapy (CRT) has emerged as a valued nonpharmacologic therapy in patients with heart failure, reduced ejection fraction (EF), and ventricular dyssynchrony manifest as left bundle branch block. The mechanisms of benefit include remodeling of the left ventricle leading to decreased dimensions and increased EF, as well as a decrease in the severity of mitral regurgitation. This article reviews the rationale, effects, and indications for CRT, and discusses the patient characteristics that predict response and considerations for nonresponders.
Ojo, A., Tariq, S., Harikrishnan, P., Iwai, S., & Jacobson, J. T. (2017). Cardiac Resynchronization Therapy for Heart Failure. Interventional Cardiology Clinics, 6 (3), 417-426. https://doi.org/10.1016/j.iccl.2017.03.010
Originally published in Interventional Cardiology Clinics, 6 (3), 417-426. The original material can be found here.