NYMC Faculty Publications

Title

The Contribution of Chymase-Dependent Formation of ANG II to Cardiac Dysfunction in Metabolic Syndrome of Young Rats: Roles of Fructose and EETs

First Page

985

Last Page

993

Document Type

Article

Publication Date

4-1-2020

Department

Physiology

Abstract

The roles of ACE-independent ANG II production via chymase and therapeutic potential of epoxyeicosatrienoic acids (EETs) in fructose-induced metabolic syndrome (MetS) in the adolescent population remain elusive. Thus we tested the hypothesis that a high-fructose diet (HFD) in young rats elicits chymase-dependent increases in ANG II production and oxidative stress, responses that are reversible by 1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-

Share

COinS