NYMC Faculty Publications

Pentose Shunt, Glucose-6-phosphate Dehydrogenase, NADPH Redox, and Stem Cells in Pulmonary Hypertension

Journal Title

Advances in Experimental Medicine and Biology

First Page

47

Last Page

55

Document Type

Article

Publication Date

January 2017

Department

Pharmacology

Abstract

Redox signaling plays a critical role in the pathophysiology of cardiovascular diseases. The pentose phosphate pathway is a major source of NADPH redox in the cell. The activities of glucose-6-phosphate dehydrogenase (the rate-limiting enzyme in the pentose shunt) and glucose flux through the shunt pathway is increased in various lung cells including, the stem cells, in pulmonary hypertension. This chapter discusses the importance of the shunt pathway and glucose-6-phosphate dehydrogenase in the pathogenesis of pulmonary artery remodeling and occlusive lesion formation within the hypertensive lungs.

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