NYMC Faculty Publications
Neprilysin Inhibition and the Treatment of Heart Failure: Recent Steps in the Right Direction
Journal Title
Cardiology in Review
First Page
315
Last Page
320
Document Type
Article
Publication Date
11-1-2017
Department
Medicine
Abstract
Numerous investigators have attempted to target the natriuretic peptide system in the treatment of heart failure since it was first described over 30 years ago. The history of neprilysin inhibition as a treatment for heart failure has been characterized by numerous setbacks. Recently, the PARADIGM-HF trial has shown favorable results, which may bring neprilysin inhibition into the mainstream of clinical practice. This article will review the history of the natriuretic peptide system and the investigations into it as a target for heart failure treatment, culminating in the positive results of the PARADIGM-HF trial, as well as planned and potential future directions for research.
Recommended Citation
Bartell, N., & Frishman, W. (2017). Neprilysin Inhibition and the Treatment of Heart Failure: Recent Steps in the Right Direction. Cardiology in Review, 25 (6), 315-320. https://doi.org/10.1097/CRD.0000000000000169
