NYMC Faculty Publications
Conditioned Serum-Free Medium From Umbilical Cord Mesenchymal Stem Cells has Anti-Photoaging Properties
Author Type(s)
Faculty
DOI
10.1007/s10529-013-1242-2
Journal Title
Biotechnology Letters
First Page
1707
Last Page
1714
Document Type
Article
Publication Date
10-1-2013
Department
Physiology
Keywords
Animals, Cell Proliferation, Cell Survival, Cells, Cultured, Culture Media, Conditioned, Culture Media, Serum-Free, Fibroblasts, Glutathione Peroxidase, Humans, Malondialdehyde, Mesenchymal Stem Cells, Mice, Skin, Superoxide Dismutase, Ultraviolet Rays, Umbilical Cord
Disciplines
Medicine and Health Sciences
Abstract
Chronic exposure to solar radiation is the primary cause of photoaging and benign and malignant skin tumors. A conditioned serum-free medium (SFM) was prepared from umbilical cord mesenchymal stem cells (UC-MSCs) and its anti-photoaging effect, following chronic UV irradiation in vitro and in vivo, was evaluated. UC-MSC SFM had a stimulatory effect on human dermal fibroblast proliferation and reduced UVA-induced cell death. In addition, UC-MSC SFM blocked UVA inhibition of superoxide dismutase activity. Topical application of UC-MSC SFM to mouse skin prior to UV irradiation blocked the inhibition of superoxide dismutase and glutathione peroxidase activities, and prevented the upregulation of malonaldehyde. UC-MSC SFM thus protects against photoaging induced by UVA and UVB radiation and is a promising candidate for skin anti-photoaging treatments.
Recommended Citation
Liu, Q., Luo, Z., He, S., Peng, X., Xiong, S., Wang, Y., Zhong, X., Zhou, X., Eisenberg, C., & Gao, B. (2013). Conditioned Serum-Free Medium From Umbilical Cord Mesenchymal Stem Cells has Anti-Photoaging Properties. Biotechnology Letters, 35 (10), 1707-1714. https://doi.org/10.1007/s10529-013-1242-2
