NYMC Faculty Publications
Fresh Frozen Plasma for Progressive and Refractory Angiotensin-Converting Enzyme Inhibitor-Induced Angioedema
Author Type(s)
Faculty
DOI
10.1016/j.jemermed.2012.07.055
Journal Title
The Journal of Emergency Medicine
First Page
764
Last Page
772
Document Type
Article
Publication Date
4-1-2013
Department
Emergency Medicine
Keywords
Aged, Angioedema, Angiotensin-Converting Enzyme Inhibitors, Blood Transfusion, Female, Humans, Male, Middle Aged, Plasma, Treatment Outcome
Disciplines
Emergency Medicine | Medicine and Health Sciences
Abstract
BACKGROUND: Angioedema secondary to angiotensin-converting enzyme inhibitors (ACEI) is a commonly encountered problem in the Emergency Department (ED). The treatment of ACEI-induced edema with conventional methods such as epinephrine, steroids, and antihistamines is usually not effective. There is limited experience using bradykinin receptor blockers and fresh frozen plasma (FFP) as a treatment modality for ACEI-induced angioedema.
OBJECTIVE: To emphasize alternative treatment option for ACEI-induced angioedema in the ED.
CASE REPORTS: We report a case series of progressive and refractory presumed ACEI-induced angioedema that all improved in temporal association with administration of FFP, with a brief review of the literature.
CONCLUSION: There was a temporal association between the administration of FFP and improvement in angioedema in seven cases of presumed ACEI-induced angioedema that were refractory to antihistamines, corticosteroids, and epinephrine.
Recommended Citation
Hassen, G., Kalantari, H., Parraga, M., Chirurgi, R., Meletiche, C., Chan, C., Ciarlo, J., Gazi, F., Lobaito, C., Tadayon, S., Yemane, S., & Velez, C. (2013). Fresh Frozen Plasma for Progressive and Refractory Angiotensin-Converting Enzyme Inhibitor-Induced Angioedema. The Journal of Emergency Medicine, 44 (4), 764-772. https://doi.org/10.1016/j.jemermed.2012.07.055
