NYMC Faculty Publications
Prevalence and Outcomes of Low Ankle Brachial Index by Atherosclerotic Cardiovascular Disease Risk Level: Insights from the National Health and Nutrition Examination Survey (NHANES)
Author Type(s)
Faculty
DOI
10.1016/j.amjms.2022.08.022
Journal Title
The American Journal of the Medical Sciences
First Page
121
Last Page
129
Document Type
Article
Publication Date
2-2023
Department
Medicine
Keywords
Humans, Adult, Middle Aged, Ankle Brachial Index, Cardiovascular Diseases, Nutrition Surveys, Prevalence, Atherosclerosis, Risk Factors, Risk Assessment
Disciplines
Medicine and Health Sciences
Abstract
BACKGROUND: Ankle brachial index (ABI) as a risk-enhancing factor in addition to the pooled cohort equation (PCE) in assessing cardiovascular risk for primary prevention of atherosclerotic cardiovascular disease (ASCVD) is uncertain.
METHODS: We analyzed data from the 1999-2004 National Health and Nutrition Examination Survey (NHANES), for 5130 participants, aged 40 and older, without known cardiovascular disease or diabetes, with available data on standard ASCVD risk and ABI. Prevalence of low ABI (ABI
RESULTS: The overall prevalence of low ABI was 3.1%. The participants with low ABI were predominantly clustered in the intermediate (33%) and high (33%) ASCVD risk categories while most participants with a normal ABI were in the low (56%) and intermediate (23%) risk categories. All-cause mortality was higher among participants with low ABI compared to those with a normal ABI in both the intermediate/borderline and high-risk categories, p
CONCLUSIONS: Using the PCE, two-third of the participants with low ABI were classified as having a low, borderline or intermediate risk of ASCVD. Low ABI was associated with an increased all-cause mortality in the overall cohort and specifically among those with a borderline/intermediate or high risk of ASCVD but not in those with a low risk of ASCVD. Our study supports consideration of ABI as a risk enhancer for primary prevention among patients classified as borderline or intermediate risk of ASCVD.
Recommended Citation
Singla, A., Chobufo, M., Meesum, A., Ali, A., Aronow, W. S., Goldsweig, A. M., Balla, S., & Whelton, P. K. (2023). Prevalence and Outcomes of Low Ankle Brachial Index by Atherosclerotic Cardiovascular Disease Risk Level: Insights from the National Health and Nutrition Examination Survey (NHANES). The American Journal of the Medical Sciences, 365 (2), 121-129. https://doi.org/10.1016/j.amjms.2022.08.022
