NYMC Faculty Publications

Benefit and Risk Evaluation of Quinapril Hydrochloride

Author Type(s)

Faculty

DOI

10.1080/14740338.2023.2203481

Journal Title

Expert Opinion on Drug Safety

First Page

271

Last Page

277

Document Type

Review Article

Publication Date

4-2023

Department

Medicine

Keywords

Humans, Aged, Quinapril, Tetrahydroisoquinolines, Isoquinolines, Antihypertensive Agents, Angiotensin-Converting Enzyme Inhibitors, Hypertension, Heart Failure

Disciplines

Medicine and Health Sciences

Abstract

INTRODUCTION: Angiotensin-converting enzyme (ACE) inhibitors are a mainstay of antihypertensive therapy. Quinapril hydrochloride, a less commonly used, and less-studied ACE inhibitor has been approved for its primary use in hypertension. Studies also indicate its off-label use for congestive heart failure and diabetic nephropathy. The ANDI and TREND trials have been pivotal in demonstrating the effectiveness of quinapril.

AREAS COVERED: The authors conducted a review of the literature analyzing the clinical efficacy and safety profile of quinapril. This review discusses the development of quinapril, provides an updated summary of the indications and contraindications, and presents a comparison with other ACE inhibitors.

EXPERT OPINION: Quinapril is a safe and well-tolerated antihypertensive medication with a favorable safety profile compared to other ACE inhibitors. However, a lack of ample recent clinical trials and post-marketing data investigating the efficacy of quinapril in large cohorts has resulted in limited use in clinical practice. Quinapril may be an effective antihypertensive option for elderly populations as well as those who cannot tolerate the side effects profiles of other ACE inhibitors and as an additional treatment option for patients with heart failure with preserved ejection fraction.

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