NYMC Faculty Publications
Sarcoendoplasmic Reticulum Calcium Transport ATPase 2a: A Potential Gene Therapy Target in Heart Failure
Author Type(s)
Faculty
DOI
10.1097/CRD.0b013e3182749cdb
Journal Title
Cardiology in Review
First Page
151
Last Page
154
Document Type
Article
Publication Date
1-1-2013
Department
Pharmacology
Keywords
Animals, Clinical Trials as Topic, Genetic Therapy, Heart Failure, Humans, Rats, Sarcoplasmic Reticulum Calcium-Transporting ATPases, Sheep
Disciplines
Medicine and Health Sciences
Abstract
The development of cardiac-specific adeno-associated viral vectors capable of long-term transgenic expression has opened new avenues in the therapeutic approach to heart failure. Failing cardiomyocytes demonstrate altered calcium-handling secondary to depressed expression and activity of myocardial sarcoendoplasmic reticulum calcium ATPase 2a (SERCA2a). This observation has led to a large body of research investigating the therapeutic utility of SERCA2a gene therapy in heart failure.
Recommended Citation
Papolos, A., & Frishman, W. H. (2013). Sarcoendoplasmic Reticulum Calcium Transport ATPase 2a: A Potential Gene Therapy Target in Heart Failure. Cardiology in Review, 21 (3), 151-154. https://doi.org/10.1097/CRD.0b013e3182749cdb
