NYMC Faculty Publications

Sarcoendoplasmic Reticulum Calcium Transport ATPase 2a: A Potential Gene Therapy Target in Heart Failure

Author Type(s)

Faculty

DOI

10.1097/CRD.0b013e3182749cdb

Journal Title

Cardiology in Review

First Page

151

Last Page

154

Document Type

Article

Publication Date

1-1-2013

Department

Pharmacology

Keywords

Animals, Clinical Trials as Topic, Genetic Therapy, Heart Failure, Humans, Rats, Sarcoplasmic Reticulum Calcium-Transporting ATPases, Sheep

Disciplines

Medicine and Health Sciences

Abstract

The development of cardiac-specific adeno-associated viral vectors capable of long-term transgenic expression has opened new avenues in the therapeutic approach to heart failure. Failing cardiomyocytes demonstrate altered calcium-handling secondary to depressed expression and activity of myocardial sarcoendoplasmic reticulum calcium ATPase 2a (SERCA2a). This observation has led to a large body of research investigating the therapeutic utility of SERCA2a gene therapy in heart failure.

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