NYMC Faculty Publications
The Existence of Myocardial Repair: Mechanistic Insights and Enhancements
Author Type(s)
Faculty
DOI
10.1097/CRD.0b013e318289d7a9
Journal Title
Cardiology in Review
First Page
111
Last Page
120
Document Type
Article
Publication Date
1-1-2013
Department
Medicine
Keywords
Bone Marrow Transplantation, Clinical Trials as Topic, Female, Heart, Heart Failure, Humans, Male, Multipotent Stem Cells, Myocardial Infarction, Regeneration, Stem Cell Transplantation
Disciplines
Medicine and Health Sciences
Abstract
The lack of myocardial repair after myocardial infarction and the heart failure that eventually ensues was thought of as proof that myocardial cell regeneration and myocardial repair mechanisms do not exist. Recently, growing experimental and clinical evidence has proven this concept wrong. Cardiac stem cells and endogenous myocardial repair mechanisms do exist; however, they do not produce significant myocardial repair. Similarly, the preliminary results of stem cell therapy for myocardial repair have shown early promise but modest results. Preclinical studies are the key to understanding stem cell senescence and lack of cellular contact and vasculature in the infarcted region. Additional laboratory studies are sure to unlock the therapeutic mechanisms that will be required for significant myocardial repair.
Recommended Citation
Schoenfeld, M., Frishman, W., Leri, A., Kajstura, J., & Anversa, P. (2013). The Existence of Myocardial Repair: Mechanistic Insights and Enhancements. Cardiology in Review, 21 (3), 111-120. https://doi.org/10.1097/CRD.0b013e318289d7a9