NYMC Faculty Publications

The Existence of Myocardial Repair: Mechanistic Insights and Enhancements

Author Type(s)

Faculty

DOI

10.1097/CRD.0b013e318289d7a9

Journal Title

Cardiology in Review

First Page

111

Last Page

120

Document Type

Article

Publication Date

1-1-2013

Department

Medicine

Keywords

Bone Marrow Transplantation, Clinical Trials as Topic, Female, Heart, Heart Failure, Humans, Male, Multipotent Stem Cells, Myocardial Infarction, Regeneration, Stem Cell Transplantation

Disciplines

Medicine and Health Sciences

Abstract

The lack of myocardial repair after myocardial infarction and the heart failure that eventually ensues was thought of as proof that myocardial cell regeneration and myocardial repair mechanisms do not exist. Recently, growing experimental and clinical evidence has proven this concept wrong. Cardiac stem cells and endogenous myocardial repair mechanisms do exist; however, they do not produce significant myocardial repair. Similarly, the preliminary results of stem cell therapy for myocardial repair have shown early promise but modest results. Preclinical studies are the key to understanding stem cell senescence and lack of cellular contact and vasculature in the infarcted region. Additional laboratory studies are sure to unlock the therapeutic mechanisms that will be required for significant myocardial repair.

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