NYMC Faculty Publications

The Natural Basil Flavonoid Nevadensin Protects Against a Methyleugenol-Induced Marker of Hepatocarcinogenicity in Male F344 Rat

Author Type(s)

Faculty

DOI

10.1016/j.fct.2014.08.016

Journal Title

Food and Chemical Toxicology

First Page

28

Last Page

34

Document Type

Article

Publication Date

12-1-2014

Department

Pathology, Microbiology and Immunology

Keywords

Animals, Body Weight, Carcinogens, DNA Adducts, Eugenol, Flavones, Liver, Liver Neoplasms, Male, Organ Size, Rats, Rats, Inbred F344

Disciplines

Medicine and Health Sciences

Abstract

The alkenylbenzene methyleugenol occurs naturally in a variety of spices and herbs, including basil, and their essential oils. At high dose levels methyleugenol induces hepatocarcinogenicity in rodents following bioactivation to 1'-sulfooxymethyleugenol which forms DNA adducts. This study investigated whether the inhibitory effect of the basil flavonoid nevadensin on sulfotransferase (SULT)-mediated bioactivation of methyleugenol observed in vitro would also be reflected in a reduction of DNA adduct formation and a reduction in an early marker for liver carcinogenesis in an 8-week rat study. Co-exposure to methyleugenol and nevadensin orally resulted in a significant inhibition of liver methyleugenol DNA adduct formation and in inhibition of hepatocellular altered foci induction, representing indicators for initiation of neoplasia. These results suggest that tumor formation could be lower in rodent bioassays when methyleugenol would be dosed in a matrix containing SULT inhibitors such as nevadensin compared to experiments using the pure methyleugenol.

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