Microbiology and Immunology
Flaviviruses including Zika, Dengue and Hepatitis C virus cause debilitating diseases in humans, and the former are emerging as global health concerns with no antiviral treatments. We investigated Sophora Flavecens, used in Chinese medicine, as a source for antiviral compounds. We isolated Sophoraflavenone G and found that it inhibited Hepatitis C replication, but not Sendai or Vesicular Stomatitis Virus. Pre- and post-infection treatments demonstrated anti-flaviviral activity against Dengue and Zika virus, via viral RNA polymerase inhibition. These data suggest that Sophoraflavenone G represents a promising candidate regarding anti-Flaviviridae research.
Sze, A., Olagnier, D., Hadj, S., Han, X., Tian, X., Xu, H., Yang, L., Shi, Q., Wang, P., Wainberg, M., Wu, J., & Lin, R. (2017). Sophoraflavenone G Restricts Dengue and Zika Virus Infection Via RNA Polymerase Interference. Viruses, 9 (10), 287. https://doi.org/10.3390/v9100287
Originally published in Viruses 2017, 9, 28. The original material can be found here.
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