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The Science Journal of the Lander College of Arts and Sciences

Abstract

Incidence of dementia has been on the rise over the last few decades and it is projected that more than 130 million people will be affected by dementia worldwide by 2050. The underlying cause remains incompletely determined, and despite numerous clinical trials, no drug to date has proven effective in preventing or reversing symptoms of cognitive decline due to Alzheimer’s disease. The amyloid hypothesis as a basis for drug development of Alzheimer’s disease has thus far proven to be ineffective, suggesting that perhaps a new approach is required. New studies have shown the efficacy of a multi-domain approach which targets several disease risk factors simultaneously, to achieve a synergistic effect on cognitive impairment. This paper analyzes a multi domain protocol, known as ReCODE protocol, developed to treat and prevent Alzheimer’s disease, and provides clinical and experimental research as well as potential mechanisms to support the key elements upon which this protocol is based. Although the results seem promising, more rigorous clinical testing is required to link this approach with prevention and reversal of cognitive decline more definitively

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