The Science Journal of the Lander College of Arts and Sciences


Atopic dermatitis, often referred to as eczema, is a chronic inflammatory skin condition frequently seen in young children. It is a complex disease involving environmental factors, genetics and immune dysregulation. There is currently no cure with conflicting opinions from physicians regarding treatment and management. A clearer understanding of pathogenesis of atopic dermatitis can hopefully lead to new and improved treatment options for patients. Current evidence seems to support epidermal skin barrier defects as the cause of this disease. This paper seeks to investigate if this out-in hypothesis can be responsible as the sole pathogenesis of atopic dermatitis. To write this paper a systematic search of online databases was conducted to find relevant studies. Through analysis of the research it can be concluded that although epidermal skin barrier defects definitely play an important role in the pathogenesis of atopic dermatitis, further research will most likely blend existing theories.



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