Lemierre's Syndrome: One Rare Disease-Two Case Studies.
WHAT IS KNOWN AND OBJECTIVE: Lemierre's syndrome is often misdiagnosed as a common cold or viral infection. Fusobacterium necrophorum is the most common causative organism. The recommended treatment regimen is 6 weeks of a beta-lactam antibiotic along with metronidazole.
CASE DESCRIPTION: We present two cases of Lemierre's syndrome with internal jugular vein thrombophlebitis and positive blood cultures for F. necrophorum. The first case was successfully treated with 6 weeks of a beta-lactam antibiotic and 4 weeks of metronidazole, while the second case was successfully treated with 4 weeks of a beta-lactam antibiotic and 2 weeks of metronidazole.
WHAT IS NEW AND CONCLUSION: Two cases of Lemierre's syndrome were treated successfully with only 2-4 weeks of metronidazole therapy. Shorter duration of metronidazole therapy should be explored in future studies.
Le, C., Gennaro, D., Marshall, D., Alaev, O., Bryan, A., Gelfman, A., & Wang, Z. (2019). Lemierre's syndrome: One rare disease—Two case studies. Journal of Clinical Pharmacy and Therapeutics, 44(1), 122-124. doi:10.1111/jcpt.12774