CASPASE-12 (CASP12) has a downregulatory function during infection and thus may protect against inflammatory disease. We investigated the distribution of CASP12 alleles (#rs497116) in African-Americans (AA) with rheumatoid arthritis (RA). CASP12 alleles were genotyped in 953 RA patients and 342 controls. Statistical analyses comparing genotype groups were performed using Kruskal–Wallis non-parametric ANOVA with Mann–Whitney U tests and chi-square tests. There was no significant difference in the overall distribution of CASP12 genotypes within AA with RA, but CASP12 homozygous patients had lower baseline joint-narrowing scores. CASP12 homozygosity appears to be a subtle protective factor for some aspects of RA in AA patients.
Marshall, L., Obaidullah, M., Fuchs, T., Fineberg, N. S., Brinkley, G., Mikuls, T. R., . . . Hermel, E. (2014). CASPASE-12 and rheumatoid arthritis in African-Americans. Immunogenetics, 66(4), 281-285.
Originally published in Immunogenetics, 66(4), 281-285. The final publication is available at Springer via http://dx.doi.org/10.1007/s00251-014-0762-9.