CASPASE-12 and Rheumatoid Arthritis in African-Americans

Authors

Laura Marshall, Touro University California
Mohammad Obaidullah, Touro University California
Trista Fuchs, Touro University CaliforniaFollow
Naomi S. Fineberg
Garland Brinkley, Touro University California
Ted R. Mikuls
Evan Hermel, Touro University CaliforniaFollow

Document Type

Article

Publication Date

2014

Abstract

CASPASE-12 (CASP12) has a downregulatory function during infection and thus may protect against inflammatory disease. We investigated the distribution of CASP12 alleles (#rs497116) in African-Americans (AA) with rheumatoid arthritis (RA). CASP12 alleles were genotyped in 953 RA patients and 342 controls. Statistical analyses comparing genotype groups were performed using Kruskal–Wallis non-parametric ANOVA with Mann–Whitney U tests and chi-square tests. There was no significant difference in the overall distribution of CASP12 genotypes within AA with RA, but CASP12 homozygous patients had lower baseline joint-narrowing scores. CASP12 homozygosity appears to be a subtle protective factor for some aspects of RA in AA patients.

Comments

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Recommended Citation

Marshall, L., Obaidullah, M., Fuchs, T., Fineberg, N. S., Brinkley, G., Mikuls, T. R., . . . Hermel, E. (2014). CASPASE-12 and rheumatoid arthritis in African-Americans. Immunogenetics, 66(4), 281-285.

Publisher's Statement

Originally published in Immunogenetics, 66(4), 281-285. The final publication is available at Springer via http://dx.doi.org/10.1007/s00251-014-0762-9.