Sleep Duration, Mortality and Stroke Among Asian Populations: A Meta-Analysis

Author Type(s)

Faculty, Resident/Fellow

Document Type

Abstract

Publication Date

3-7-2023

Journal Title

Journal of the American College of Cardiology

Department

Medicine

Abstract

Background

Sleep is increasingly recognized as an important contributor to health. The association between sleep duration and mortality appears stronger in Asian populations in previous prospective studies. Therefore, we focused on this population to study via meta-analysis the effect of sleep duration on cardiovascular (CV) outcomes in Asians.

Methods

A comprehensive search of the literature was performed through September 2022 for all studies evaluating the effect of sleep duration on cardiovascular outcomes in Asian populations. The hazard ratio (HR) with 95% confidence interval (CI) was computed using a random-effects model using 7-8 hours (hrs) of sleep per night as reference.

Results

A total of 23 studies including 1,073,636 participants were included in the final analysis. The mean age was 60.5+6.5 years and 52.6% were men. Median follow-up period was 8.05 years. In the pooled analysis, there was a U-shaped association between sleep duration and outcomes. Compared to 7-8 hrs of sleep, both shorter (≤ 5) and longer (≥10) sleep duration was associated with increased risk of all-cause mortality. [HR 1.10(95%CI (1.04,1.17), 1.53(95% CI 1.42-1.64) respectively). There was similar effect of sleep duration on CV mortality and stroke. (Figure 1) The highest risk was with >10 hrs, with >50% increase in the risk of all outcomes.

Conclusion

Both shorter and longer duration sleep, compared to 7-8 hrs of sleep, are associated with a dose-dependent increased risk of mortality and stroke in Asian populations.

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