Additional Author Affiliation
Microbiology and Immunology
This work lays the foundation for investigation into the role of PD-L1 in thyroid cancer. It is the first study to show the potential link between androgen, androgen receptor, and the immune checkpoint molecule, PD-L1. Androgen may provide a protective advantage in males against thyroid cancer by decreasing PD-L1 expression thereby allowing T cell infiltration and elimination of tumors, and could potentially offer an explanation as to the lower thyroid cancer incidence in men. Higher expression levels of PD-L1 in female thyroid cancer patients may indicate an opportunity for sex-based therapeutics.
O'Connell, Timmy; Jones, Melanie E.; Gupta, Anvita; Lando, Tali; Jourdy, Deya; Moscatello, Augustine; Tiwari, Raj K.; and Geliebter, Jan, "Androgen Receptor Stimulation Decreases PD-L1 Expression in an Androgen-responsive Thyroid Cancer Model" (2017). NYMC Faculty Posters. 27.