Successful Treatment of Ibrutinib-Associated Central Nervous System Hemorrhage with Platelet Transfusion Support

Authors

Karen Seiter, New York Medical CollegeFollow
Michael Stiefel, New York Medical CollegeFollow
Azfar Shaikh, New York Medical College
Nasir Ahmed, New York Medical College
Paul Baskind, New York Medical College
Delong Liu, New York Medical CollegeFollow

First Page

27

Last Page

27

Document Type

Article

Publication Date

7-4-2016

Department

Medicine

Second Department

Neurosurgery

Abstract

Ibrutinib is a novel targeted therapy for B-cell malignancies. Hemorrhagic events were reported in the original trials, however the mechanism of bleeding is just being elucidated. Recent studies have demonstrated platelet dysfunction as a mechanism of bleeding. Currently we report two patients who developed life-threatening central nervous system hemorrhage while receiving ibrutinib for chronic lymphoid leukemia (CLL) and mantle cell lymphoma, respectively. Both patients improved rapidly after platelet transfusions even though their platelet counts were normal or only mildly reduced at the time of hemorrhage. We suggest that platelet transfusions can ameliorate the platelet dysfunction defect of ibrutinib and can support the patient through the critical period until new platelet production occurs.

Comments

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Recommended Citation

Seiter, K., Stiefel, M. F., Barrientos, J., Shaikh, A., Ahmed, N., Baskind, P., & Liu, D. (2016). Successful treatment of ibrutinib-associated central nervous system hemorrhage with platelet transfusion support. Stem Cell Investigation, 3, 27. doi:10.21037/sci.2016.06.08

Publisher's Statement

Originally published in Stem Cell Investigation. Licensed under CC-BY 4.0. https://doi.org/10.21037/sci.2016.06.08