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The Science Journal of the Lander College of Arts and Sciences

Abstract

Alzheimer’s disease is a neurodegenerative condition which results in a significant decline in cognitive status. Novel treatment approaches for Alzheimer’s are sorely needed, as current medications for the disease offer only marginal clinical benefit. Research has discovered a connection between the pathology of Alzheimer’s and Type 2 Diabetes, two serious and seemingly unrelated disorders. Clinical studies have shown that Alzheimer’s disease is associated with brain insulin resistance similar to the pathology of Type 2 Diabetes. This observation has led to the notion that drugs developed for the treatment of Type 2 Diabetes may be beneficial in modifying the cognitive function and pathophysiology of individuals suffering from Alzheimer’s disease. This paper offers a comprehensive review of the clinical studies demonstrating the potential of using diabetes medications as an effective therapeutic method for the prevention and treatment of Alzheimer’s disease. Special focus is given towards the metabolic hormones insulin, amylin and leptin.

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