Gene therapy is the use of genes to treat or prevent diseases. Diseases such as cancer, which are difficult to treat using conventional methods, can be treated using gene therapy. The transport of the therapeutic transgene can be accomplished using viral or non-viral methods. However, widespread use of viral vectors is limited due to its high cost of manufacture and safety concern. Non-viral vectors are limited in their effectiveness. The use of transposons such as the Sleeping Beauty transposon system can effectively deliver the transgene with less concern than viral vectors. This review discusses the various vectors and treatment strategies using gene therapy to treat cancer.
Stauber, J. (2015). Transposon Based Gene Therapy as a Treatment for Cancer. The Science Journal of the Lander College of Arts and Sciences, 8 (2). Retrieved from http://touroscholar.touro.edu/cgi/viewcontent.cgi?article=1065&context=sjlcas