NYMC Faculty Publications
Genomic Analysis Reveals Distinct Subtypes in Two Rare Cases of Primary Ovarian Lymphoma
Journal Title
Pathology, Research and Practice
First Page
593
Last Page
598
Document Type
Article
Publication Date
April 2018
Department
Pathology, Microbiology and Immunology
Abstract
Primary (localized) non-Hodgkin lymphoma (NHL) of the ovary is extremely rare; only a few cases have been reported in the literature. We report two cases of primary ovarian lymphoma (POL), one involving bilateral ovaries in a 15-year-old girl and other involving one ovary in a 5-year-old girl. This report describes detailed clinical, histopathological, and imaging findings, along with the review of literature of primary diffuse large B-cell lymphoma (DLBCL) arising from an ovary. In addition, we describe findings of targeted capture panel sequencing on both tumors and identify the major genetic mutations that are recurrently mutated in pan-cancers. Compared to the genomic mutation features of major subtypes of DLBCL, we distinguish that each POL belongs to distinctive subtypes, GCB (germinal center B-cell subtype) DLBCL and ABC (activated B-cell subtype) DLBCL, respectively. The findings from the genomic analysis may help to understand the pathogenesis of POL and to guide potential targeted therapy in the future.
Recommended Citation
Khattar, P., Bedi, P., Gonzalez, M., Zhong, M., Yin, C., Huang, W., Islam, H., & Fallon, J. (2018). Genomic Analysis Reveals Distinct Subtypes in Two Rare Cases of Primary Ovarian Lymphoma. Pathology, Research and Practice, 214 (4), 593-598. https://doi.org/10.1016/j.prp.2017.12.017
