The Role of the Stringent Response in the Pathogenesis of Bacterial Infections
Microbiology and Immunology
Precise regulatory control of bacterial gene activation is crucial for the adaptation of pathogens to the hostile microniches of their hosts. The role of one of these global regulators, the stringent response, in pathogen virulence and persistence has recently become a favoured area of research. The complexity and multiplicity of the bacterial genes and regulatory pathways affected by the stringent response suggest that the relationship between the stringent response and virulence could be considerably more complex than expected and is perhaps unique for each pathogen and for each set of virulence properties that it regulates.
Godfrey, H. P., Bugrysheva, J., & Cabello, F. (2002). The Role of the Stringent Response in the Pathogenesis of Bacterial Infections. Trends in Microbiology, 10 (8), 349-351. https://doi.org/10.1016/S0966-842X(02)02403-4