Epidemiology and Community Health
OBJECTIVES: Predicting mortality in middle-aged HIV-infected (HIV+) women on antiretroviral therapies (ART) is important for understanding the impact of HIV infection. Several health indices have been used to predict mortality in women with HIV infection. We evaluated: (1) an HIV biological index, Veterans Aging Cohort Study (VACS); (2) a physical index, Fried Frailty Index (FFI); and (3) a mental health index, Center for Epidemiologic Studies-Depression (CES-D). Proportional hazards regression analyses were used to predict death and included relevant covariates.
DESIGN: Prospective, observational cohort.
SETTING: Multicentre, across six sites in the USA.
PARTICIPANTS: 1385 multirace/ethnic ART-experienced HIV+ women in 2005.
PRIMARY AND SECONDARY OUTCOMES: All deaths, AIDS deaths and non-AIDS deaths up to ~8 years from baseline.
RESULTS: Included together in one model, VACS Index was the dominant, significant independent predictor of all deaths within 3 years (HR=2.20, 95% CI 1.83, 2.65, χ
CONCLUSIONS AND RELEVANCE: This is the first simultaneous evaluation of three common health indices in HIV+ adults. Indices reflecting physical and biological ageing were associated with death.
Gustafson, D., Shi, Q., Holman, S., Minkoff, H., Cohen, M., Plankey, M., & Hoover, D. (2017). Predicting Death Over 8 Years in a Prospective Cohort of HIV-Infected Women: The Women's Interagency HIV Study. BMJ Open, 7 (6), 013993-013993. https://doi.org/10.1136/bmjopen-2016-013993
Originally published in BMJ Open, 7 (6), 013993-013993. The original material can be found here.
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