NYMC Faculty Publications

De Novo CD5+ Primary Gastrointestinal Diffuse Large B-Cell Lymphoma: Challenges With Treatment and Clinical Course

DOI

10.1177/2324709619893546

Journal Title

Journal of Investigative Medicine High Impact Case Reports

First Page

2324709619893546

Last Page

2324709619893546

Document Type

Article

Publication Date

1-1-2019

Department

Medicine

Abstract

The gastrointestinal tract is a common extranodal site for lymphomas. However, primary gastrointestinal lymphomas are rare. Diffuse large B-cell lymphomas (DLBCL) are the most commonly encountered type in the gastrointestinal tract. Most of the DLBCL are CD5 negative. CD5+ DLBCL is very rare and a poor prognostic subtype of lymphoma. We report a rare case of primary small bowel CD5+ DLBCL that evolved from being a localized low International Prognostic Index-scored disease into an advanced and aggressive disease primarily dictated by the presence of CD5 antigen positivity.

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