Epigenetics- Epidisease- Epidrug: A Key Context Folded Inside of Periodontal Diseases
Environmental Health Science
Compelling evidence has covered potential risks that may trigger a wide spectrum of illnesses (e.g., cardiovascular, stroke, mental diseases, rheumatoid arthritis, and diabetes) in association with chronic inflammatory events. Of the inflammatory events, the focus of this review is on periodontitis. Periodontitis facilitates an oxidative stress-mediated, imbalanced immune system through aberrant epigenetic regulatory machinery. Connectivity default, as a chain of surveillance (or immune) system between genomics and epigenetic modules, lead to onset of disease pathogenesis. The method to link the sensitivity in epigenetic molecular networks and vulnerability against various environmental threats is still unclear. Advents new era of omics include advanced traditional imaging skills and its tools, and oral health care by adapting new paradigm of epigenomes, which could reduce potential risk such as chronic periodontics disease, followed by other secondary disorders. A part of the epigenetic, post-translation approach could contribute to the prevention and prediction scale in personalized sampling and analyzed outcomes, which are being updated by empowering systematic assessments from bench to clinic after uploading them with molecular epigenetic tools. Current progress in drug development application unveils the connective value of epigenetic in terms of sequential molecular deficit, referring to infection pathogenesis focus on advanced periodontal disease- periodontitis. In addition, Health burden is increasing with the aging population and must be considered in order to reduce medical expenses and improve quality of disease monitoring and surveillance (QDMS). Therefore, another connective value is lessening health burden by understanding the impact of epigenome as countermeasures in the future asset.
Patel, D., Lee, Y. J., Chauhan, B. P., Sidhu, L., Heck, D. E., & Kim, H. D. (2019). Epigenetics- Epidisease- Epidrug: A Key Context Folded Inside of Periodontal Diseases. Enliven: Dentistry and Peridontics, 1 (1), 001-004. Retrieved from https://touroscholar.touro.edu/nymc_fac_pubs/2423