in Utero Vertical Transmission of Coronavirus Disease 2019 in a Severely Ill 29-Week Preterm Infant
Severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) or coronavirus disease 2019 (COVID-19) is currently in worldwide pandemic state with very limited data about the mode of transmission to the growing fetus. There are a few published cases of COVID-19 infection in the infants born to COVID-19 positive mothers where most of the reported cases were either mildly symptomatic with positive COVID-19 polymerase chain reaction (PCR) or had negative COVID-19 PCR raising the question of vertical transmission. We present a case of likely intrauterine transmission of COVID-19 infection in a critically ill premature infant born to a COVID-19 infected mother and describing her clinical course thus far. The clinical presentation in the infant is consistent with COVID-19 infection described so far in literature along with positive PCR, and positive COVID-19 serology: immunoglobulin G, immunoglobulin M, and immunoglobulin A.
Gupta, A., Malhotra, Y., Patil, U., Muradas, A. R., Lee, W. T., Krammer, F., Amanat, F., Clare, C. A., Vinod, S., & Ghaly, E. (2020). in Utero Vertical Transmission of Coronavirus Disease 2019 in a Severely Ill 29-Week Preterm Infant. AJP Reports, 10 (3), 270-270. https://doi.org/10.1055/s-0040-1715177