NYMC Faculty Publications

Title

Impact of Type of Reduced-Intensity Conditioning Regimen on the Outcomes of Allogeneic Haematopoietic Cell Transplantation in Classical Hodgkin Lymphoma

First Page

573

Last Page

582

Document Type

Article

Publication Date

8-2020

Department

Pediatrics

Second Department

Health Behavior and Community Health

Abstract

Reduced-intensity conditioning (RIC) allogeneic haematopoietic cell transplantation (allo-HCT) is a curative option for select relapsed/refractory Hodgkin lymphoma (HL) patients; however, there are sparse data to support superiority of any particular conditioning regimen. We analyzed 492 adult patients undergoing human leucocyte antigen (HLA)-matched sibling or unrelated donor allo-HCT for HL between 2008 and 2016, utilizing RIC with either fludarabine/busulfan (Flu/Bu), fludarabine/melphalan (Flu/Mel140) or fludarabine/cyclophosphamide (Flu/Cy). Multivariable regression analysis was performed using a significance level of

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