NYMC Faculty Publications

Impact of Type of Reduced-Intensity Conditioning Regimen on the Outcomes of Allogeneic Haematopoietic Cell Transplantation in Classical Hodgkin Lymphoma

DOI

10.1111/bjh.16664

Journal Title

British Journal of Haematology

First Page

573

Last Page

582

Document Type

Article

Publication Date

8-2020

Department

Pediatrics

Second Department

Health Behavior and Community Health

Keywords

Adolescent, Adult, Aged, Allografts, Busulfan, Cause of Death, Comorbidity, Cyclophosphamide, Female, Graft vs Host Disease, Hematopoietic Stem Cell Transplantation, Hodgkin Disease, Humans, Kaplan-Meier Estimate, Male, Melphalan, Middle Aged, Myeloablative Agonists, Progression-Free Survival, Recurrence, Siblings, Transplantation Conditioning, Unrelated Donors, Vidarabine, Young Adult

Disciplines

Medicine and Health Sciences

Abstract

Reduced-intensity conditioning (RIC) allogeneic haematopoietic cell transplantation (allo-HCT) is a curative option for select relapsed/refractory Hodgkin lymphoma (HL) patients; however, there are sparse data to support superiority of any particular conditioning regimen. We analyzed 492 adult patients undergoing human leucocyte antigen (HLA)-matched sibling or unrelated donor allo-HCT for HL between 2008 and 2016, utilizing RIC with either fludarabine/busulfan (Flu/Bu), fludarabine/melphalan (Flu/Mel140) or fludarabine/cyclophosphamide (Flu/Cy). Multivariable regression analysis was performed using a significance level of

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