Impact of Type of Reduced-Intensity Conditioning Regimen on the Outcomes of Allogeneic Haematopoietic Cell Transplantation in Classical Hodgkin Lymphoma

Authors

Sairah Ahmed
Mitchell Cairo, New York Medical CollegeFollow
Mehdi Hamadani

DOI

10.1111/bjh.16664

Journal Title

British Journal of Haematology

First Page

573

Last Page

582

Document Type

Article

Publication Date

8-2020

Department

Pediatrics

Second Department

Health Behavior and Community Health

Abstract

Reduced-intensity conditioning (RIC) allogeneic haematopoietic cell transplantation (allo-HCT) is a curative option for select relapsed/refractory Hodgkin lymphoma (HL) patients; however, there are sparse data to support superiority of any particular conditioning regimen. We analyzed 492 adult patients undergoing human leucocyte antigen (HLA)-matched sibling or unrelated donor allo-HCT for HL between 2008 and 2016, utilizing RIC with either fludarabine/busulfan (Flu/Bu), fludarabine/melphalan (Flu/Mel140) or fludarabine/cyclophosphamide (Flu/Cy). Multivariable regression analysis was performed using a significance level of

Comments

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Recommended Citation

Ahmed, S., Cairo, M., & Hamadani, M. (2020). Impact of Type of Reduced-Intensity Conditioning Regimen on the Outcomes of Allogeneic Haematopoietic Cell Transplantation in Classical Hodgkin Lymphoma. British Journal of Haematology, 190 (4), 573-582. https://doi.org/10.1111/bjh.16664