Heme Oxygenase-1 Upregulation: A Novel Approach in the Treatment of Cardiovascular Disease
SIGNIFICANCE: Heme oxygenase (HO) plays a pivotal role in both vascular and metabolic function and is involved in many physiological and pathophysiological processes in vascular endothelial cells and adipocytes. Recent advances: From the regulation of adipogenesis in adipose tissue to the adaptive response of vascular tissue in the endothelial cells, HO plays a critical role in the ability of the vascular system to respond and adapt to insults in homeostasis. Recent studies show that HO-1 through regulation of adipocyte and adipose tissue functions ultimately aid not only in local, but systemic maintenance of homeostasis. CRITICAL ISSUES: Recent advances have revealed the existence of a crosstalk between vascular endothelial cells and adipocytes in adipose tissue. In the pathological state of obesity, this crosstalk contributes to the condition's adverse chronic effects and we propose that specific targeting of the HO-1 gene can restore signaling pathways and improve both vascular and adipose function. FUTURE DIRECTIONS: A complete understanding of the role of heme oxygenase 1 in regulation of cardiovascular homeostasis is important to comprehend the homeostatic regulation as well as in cardiovascular disease. Efforts are required to highlight the effects and the ability to target the
HO-1 gene in models of obesity with an emphasis on the role of pericardial fat on cardiovascular health.
Bellner, L., Lebovics, N. B., Rubinstein, R., Buchen, Y. D., Sinatra, E., Sinatra, G., Abraham, N. G., McClung, J. A., & Thompson, E. A. (2020). Heme Oxygenase-1 Upregulation: A Novel Approach in the Treatment of Cardiovascular Disease. Antioxidants & Redox Signaling, 32 (14), 1045-1060. https://doi.org/10.1089/ars.2019.7970