Evaluation of the Role of Oral Penicillin for Treating Lyme Disease Patients with Erythema Migrans in the United States
Clinical trials of oral penicillin preparations in the United States for treating Lyme disease patients with erythema migrans are limited to 2 studies. The results of these studies demonstrated a less than optimal outcome of this treatment. However, there were serious methodologic concerns in both studies precluding the interpretation that phenoxymethylpenicillin specifically should be regarded as ineffective. Therefore, additional clinical trials should be conducted in the United States with close attention to the dose and duration of treatment that have been used very successfully in Europe.
Wormser, G. P., & Strle, F. (2020). Evaluation of the Role of Oral Penicillin for Treating Lyme Disease Patients with Erythema Migrans in the United States. Diagnostic Microbiology and Infectious Disease, 97 (4), 115071-115071. https://doi.org/10.1016/j.diagmicrobio.2020.115071