Case Report: Buprenorphine-A Treatment for Psychological Pain and Suicidal Ideation?
Psychiatry and Behavioral Sciences
BACKGROUND AND OBJECTIVES: Buprenorphine is commonly used to manage opioid use disorder; however, the literature describes its potential role in treating treatment-resistant depression.
METHODS: We present a patient with bipolar disorder and opioid use disorder, who presented status post-suicide attempt.
RESULTS: After initiating buprenorphine-naloxone, the patient reported rapid improvement in depressive symptoms, pain, and suicidal ideation.
DISCUSSION AND CONCLUSIONS: This case demonstrates buprenorphine's antisuicidal and mood-stabilizing capabilities, potentially via antagonizing κ-opioid receptors as well as reinstating the balance between reward and antireward circuitry.
SCIENTIFIC SIGNIFICANCE: This case highlights buprenorphine-naloxone as a treatment for both treatment-resistant depression and opioid use disorder, as well as buprenorphine's rapid antidepressant, analgesic, and antisuicidal effects. (Am J Addict 2021;30:80-82).
Benhamou, O., Lynch, S., & Klepacz, L. (2021). Case Report: Buprenorphine-A Treatment for Psychological Pain and Suicidal Ideation?. The American Journal on Addictions, 30 (1), 80-82. https://doi.org/10.1111/ajad.13063