NYMC Faculty Publications
The Salivary Metatranscriptome as an Accurate Diagnostic Indicator of Oral Cancer
Author Type(s)
Faculty
DOI
10.1038/s41525-021-00257-x
Journal Title
NPJ Genomic Medicine
First Page
105
Last Page
105
Document Type
Article
Publication Date
12-8-2021
Department
Pharmacology
Second Department
Pathology, Microbiology and Immunology
Abstract
Despite advances in cancer treatment, the 5-year mortality rate for oral cancers (OC) is 40%, mainly due to the lack of early diagnostics. To advance early diagnostics for high-risk and average-risk populations, we developed and evaluated machine-learning (ML) classifiers using metatranscriptomic data from saliva samples (n = 433) collected from oral premalignant disorders (OPMD), OC patients (n = 71) and normal controls (n = 171). Our diagnostic classifiers yielded a receiver operating characteristics (ROC) area under the curve (AUC) up to 0.9, sensitivity up to 83% (92.3% for stage 1 cancer) and specificity up to 97.9%. Our metatranscriptomic signature incorporates both taxonomic and functional microbiome features, and reveals a number of taxa and functional pathways associated with OC. We demonstrate the potential clinical utility of an AI/ML model for diagnosing OC early, opening a new era of non-invasive diagnostics, enabling early intervention and improved patient outcomes.
Recommended Citation
Banavar, G., Ogundijo, O., Toma, R., Rajagopal, S., Lim, Y., Tang, K., Camacho, F., Torres, P. J., Gline, S., Parks, M., Kenny, L., Perlina, A., Tily, H., Dimitrova, N., Amar, S., Vuyisich, M., & Punyadeera, C. (2021). The Salivary Metatranscriptome as an Accurate Diagnostic Indicator of Oral Cancer. NPJ Genomic Medicine, 6 (1), 105-105. https://doi.org/10.1038/s41525-021-00257-x
