The Effect of Cardiac Geometry Variation According to Sex and Race on Outcomes in Patients with Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention
INTRODUCTION: The prevalence and long-term consequences of differences in baseline cardiac geometry (as a result of hypertension) in patients undergoing percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS) are ill-defined. The primary purpose of this study was to clarify whether there were differences among sexual and racial groups in echocardiographic findings reflecting cardiac geometry and adaptation in patients undergoing PCI for ACS and whether this could explain the differences in outcomes seen between these groups.
MATERIAL AND METHODS: We analyzed 1-year follow-up data from a single institution, a retrospective, observational study that enrolled 1,153 patients who presented with ACS and were treated with PCI, for whom echocardiographic data were available.
RESULTS: Normal, concentric hypertrophy, and eccentric hypertrophy in males vs. females were observed as follows: 29% vs. 19% (
CONCLUSIONS: Females undergoing PCI for ACS are at higher risk for worse outcomes because they are more likely to express the eccentric hypertrophy phenotype; however, it did not account for the difference in adverse outcomes observed between sexes.
Ha, E. T., Cohen, M., Gaeta, T. J., Parikh, M. A., Peterson, S. J., & Aronow, W. S. (2021). The Effect of Cardiac Geometry Variation According to Sex and Race on Outcomes in Patients with Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention. Archives of Medical Sciences. Atherosclerotic Diseases, 6, 152-159. https://doi.org/10.5114/amsad.2021.107908