NYMC Faculty Publications
Migratory Cortical Interneuron-Specific Transcriptome Abnormalities in Schizophrenia
Author Type(s)
Faculty
DOI
10.1016/j.jpsychires.2021.02.054
Journal Title
Journal of Psychiatric Research
First Page
111
Last Page
116
Document Type
Article
Publication Date
5-2021
Department
Cell Biology and Anatomy
Second Department
Pathology, Microbiology and Immunology
Third Department
Pathology, Microbiology and Immunology
Keywords
Humans, Induced Pluripotent Stem Cells, Interneurons, Schizophrenia, Transcriptome
Disciplines
Medicine and Health Sciences
Abstract
Cortical interneurons (cINs) are substantially affected in Schizophrenia (SCZ) and enriched for SCZ heritability during development. To understand SCZ-specific changes in these cells during development, we isolated migratory cINs from cIN spheres derived from 5 healthy control (HC) and 5 SCZ induced pluripotent stem cell lines (iPSCs). Transcriptome analyses show dysregulation in extracellular matrix pathways as the major disturbances in SCZ migratory cINs, whereas sphere cINs show dysregulation in immune pathways. This result suggests the importance of using homogeneous cell populations to identify stage-specific abnormalities and provides a platform to further study the biology of schizophrenia pathogenesis during early development.
Recommended Citation
Park, J. M., Liu, D., Park, G., Noh, H., Ni, P., Yin, C., Huang, W., & Chung, S. (2021). Migratory Cortical Interneuron-Specific Transcriptome Abnormalities in Schizophrenia. Journal of Psychiatric Research, 137, 111-116. https://doi.org/10.1016/j.jpsychires.2021.02.054
