NYMC Faculty Publications

Migratory Cortical Interneuron-Specific Transcriptome Abnormalities in Schizophrenia

Author Type(s)

Faculty

DOI

10.1016/j.jpsychires.2021.02.054

Journal Title

Journal of Psychiatric Research

First Page

111

Last Page

116

Document Type

Article

Publication Date

5-2021

Department

Cell Biology and Anatomy

Second Department

Pathology, Microbiology and Immunology

Third Department

Pathology, Microbiology and Immunology

Abstract

Cortical interneurons (cINs) are substantially affected in Schizophrenia (SCZ) and enriched for SCZ heritability during development. To understand SCZ-specific changes in these cells during development, we isolated migratory cINs from cIN spheres derived from 5 healthy control (HC) and 5 SCZ induced pluripotent stem cell lines (iPSCs). Transcriptome analyses show dysregulation in extracellular matrix pathways as the major disturbances in SCZ migratory cINs, whereas sphere cINs show dysregulation in immune pathways. This result suggests the importance of using homogeneous cell populations to identify stage-specific abnormalities and provides a platform to further study the biology of schizophrenia pathogenesis during early development.

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