Role of Cystatin C in Predicting Disease Activity and Flare-Up in Systemic Lupus Erythematosus: A Longitudinal Follow-Up Study
International Journal of Preventive Medicine
BACKGROUND: We aimed to determine the sensitivity of serum cystatin C (Cys-C) in predicting lupus flare-up.
METHODS: In a longitudinal study, 77 patients were followed-up for up to 15 months. Cys-C, physician global assessment (PGA), and lupus activity index (SLEDAI) were recorded during each visit. Flare-up was defined as an increase ≥4 scores in SLEDAI compared to the last visit. The predictability of flare-up by Cys-C was evaluated by generalized linear-mixed effect model (GLMM) and generalized estimating equation (GEE). Predictive power of Cys-C, SLEDAI, and PGA was compared by the area under the curves (AUC) and application of receiver operating characteristic (ROC) curves.
RESULTS: Lupus flare-up was observed in 14 out of 77 patients on the 1
CONCLUSIONS: Although Cys-C had some sensitivity for predicting flare-up, active nephritis or SLEDAI, its sensitivity was lower than that in PGA and SLEDAI.
Fatemi, A., Rahami, Z., & Smiley, A. (2021). Role of Cystatin C in Predicting Disease Activity and Flare-Up in Systemic Lupus Erythematosus: A Longitudinal Follow-Up Study. International Journal of Preventive Medicine, 12, 63-63. https://doi.org/10.4103/ijpvm.IJPVM_619_20