A Review of the Role of Type 2 Diabetes Mellitus and Sodium-Glucose Cotransporter-1 Inhibitors in Heart Failure With Preserved Ejection Fraction
Previous research has demonstrated that patients with type 2 diabetes (T2DM) are at an increased risk for cardiovascular events, including heart failure (HF). Moreover, there is a higher risk of mortality in individuals who have both T2DM and HF with preserved ejection fraction (HFpEF). Although there are antidiabetic agents that have shown both cardiovascular safety and improved cardiovascular outcomes, only certain agents have been associated with HF benefits, such as sodium-glucose cotransporter-2 (SGLT2) inhibitors. This study aims to review the pathophysiology of HFpEF in the setting of T2DM and, more specifically, the role of SGLT2 inhibitors in HFpEF outcomes.
Palaguachi, G. I., & Frishman, W. (2022). A Review of the Role of Type 2 Diabetes Mellitus and Sodium-Glucose Cotransporter-1 Inhibitors in Heart Failure With Preserved Ejection Fraction. https://doi.org/10.1097/CRD.0000000000000399