NYMC Faculty Publications

The Additive Effect of Clonidine to Lidocaine on Postoperative Pain Management After Root Canal Treatment on Mandibular Molars with Symptomatic Irreversible Pulpitis: A Prospective Randomised Double-Blind Clinical Trial

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Journal of Conservative Dentistry

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Dental Medicine


CONTEXT: Postoperative pain control has been a common challenge to clinicians in endodontics.

AIMS: This double-blind randomized clinical trial assessed the efficacy of clonidine added to lidocaine for postoperative pain following endodontic treatment of mandibular molars with symptomatic irreversible pulpitis (SIP).

METHODS: One hundred participants with lower molars experiencing SIP were recruited and randomly assigned to two groups. 1.8 mL of 2% lidocaine with either epinephrine (1:80,000) or clonidine (15 µg/mL) was administered to each group via an inferior alveolar nerve block. A Heft-Parker Visual Analog Scale was used to rate preoperative pain and at 6, 12, 24, 36, 48, and 72 h following endodontic treatment. Their postoperative analgesic consumption was recorded.

STATISTICAL ANALYSIS USED: The analgesic efficacy was analyzed by Chi-square test, paired

RESULTS: Early postoperative pain was significantly lower in the lidocaine/clonidine group than the lidocaine/epinephrine group (6 h:

CONCLUSIONS: The administration of clonidine added to lidocaine may reduce early postoperative pain and consumption of analgesics following endodontic treatment in lower molars with SIP.