NYMC Faculty Publications

Autism Spectrum Disorder and Molecular Imaging Following Environmental Stress: Functional Aspects of the Risk Using Multi-Omics

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GSC Biological and Pharmaceutical Sciences

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Document Type

Review Article

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Environmental Health Science


Autism Spectrum Disorder (ASD) is characterized by complicated phenotypic symptoms, including intervention with social activity, communication, and unusually behavioral abnormality. ASD is a lifelong developmental condition affecting one in 88 children and is considered one of today's most urgent public health challenges. Individuals with ASD tend to respond inappropriately in conversation and may struggle to build relationships. Currently, the prime cause of ASD remains unclear, even though emerging findings emphasize the role of genetic and environmental factors in the development of autistic behavior could be examined. At present, risks such as exposure to unknown chemicals as an environmental factor in ASD are less appreciated. This review will discuss potential risks include air pollution and particle matters in alignment with detection strategies, like multidimensional Omics and the transcriptomic approach, which may empower the capability of predicting potential risk from gene expression to phenotype level as a hallmark of transformation outcome. In addition, this genomic-driven validation process saves time and quality of accuracy in the process of finding molecular determinants in the early stage of disease onset. Currently, the genomics era brings prediction models with various algorithms, and its intervention alternatives speed up to analyze the environmental risk of chemical stressors, such as hazardous chemicals, air pollutants, and/or nanoparticles, in compliance with regulatory measures of exploring molecular determinants associated with chronic disease and metabolic disorders. The value chain of disease prevention along with surveillance platform closely interacts with the prediction of risk assessment using a molecular-based platform. Efficacy of a sequential workout, including exploring, monitoring, and the translational application process in cellular or in vitro systems, could crosstalk with a transgenic animal model. Targeting molecule implication, such as gain- or loss-of-functional reverse genetic technology to verify its functional analysis, multi-dimensional omics could be beneficial in the field of environmental risk assessment, including safety evaluation: food and drug screening in ASD combined with imaging technology.