NYMC Faculty Publications
A New Potential Approach to Inotropic Therapy in the Treatment of Heart Failure: Urocortin
Author Type(s)
Faculty
DOI
10.1097/CRD.0b013e31827ed0c9
Journal Title
Cardiology in Review
First Page
160
Last Page
165
Document Type
Article
Publication Date
1-1-2013
Department
Pharmacology
Abstract
Urocortins (UCNs), peptides that belong to the corticotrophin-releasing hormone family, represent a novel group of inotropic agents that have a multifaceted effect on the body with significant effects on the cardiovascular, hemodynamic, neurohormonal, and renal systems. UCNs can potentially improve the overall picture of heart failure by targeting not only the cardiovascular and hemodynamic systems like many current inotropic agents but also other systemic tissues that contribute significantly to the mortality and morbidity of heart failure. The 3 types of UCNs (1, 2, and 3) have been shown in preclinical studies to be effective in improving cardiovascular, neurohormonal, and renal function. UCN 2 has been shown in clinical studies to induce significant cardiovascular benefit with limited systemic effects. UCNs, specifically UCNs 2 and 3, show great potential as additional treatment in the management of systolic heart failure.
Recommended Citation
Garg, V., & Frishman, W. (2013). A New Potential Approach to Inotropic Therapy in the Treatment of Heart Failure: Urocortin. Cardiology in Review, 21 (3), 160-165. https://doi.org/10.1097/CRD.0b013e31827ed0c9
