Elevated Level of Pro-Inflammatory Eicosanoids and EPC Dysfunction in Diabetic Patients With Cardiac Ischemia

Authors

Yossi Issan
Edith Hochhauser
Austin M. Guo, New York Medical CollegeFollow
Katherine H Gotlinger
Ran Kornowski
Dorit Leshem-Lev
Eli Lev
Eyal Porat
Eitan Snir
Carl Thompson, New York Medical CollegeFollow
Nader G. Abraham, New York Medical CollegeFollow
Michal A. Schwartzman, Touro CollegeFollow

Author Type(s)

Faculty

Additional Author Affiliation

Touro College

DOI

10.1016/j.prostaglandins.2012.12.002

Journal Title

Prostaglandins & Other Lipid Mediators

First Page

15

Last Page

21

Document Type

Article

Publication Date

1-1-2013

Department

Pharmacology

Abstract

BACKGROUND: Circulating endothelial progenitor cells (EPCs) are recruited from the blood system to sites of ischemia and endothelial damage, where they contribute to the repair and development of blood vessels. Since numerous eicosanoids including leukotrienes (LTs) and hydroxyeicosatetraenoic acids (HETEs) have been shown to exert potent pro-inflammatory activities, we examined their levels in chronic diabetic patients with severe cardiac ischemia in conjunction with the level and function of EPCs.

RESULTS: Lipidomic analysis revealed a diabetes-specific increase (p

CONCLUSION: This study demonstrates a close association between elevated levels of highly pro-inflammatory eicosonoids, diabetes and EPC dysfunction in patients with cardiac ischemia, indicating that chronic inflammation impact negatively on EPC function and angiogenic capacity in diabetes.

Recommended Citation

Issan, Y., Hochhauser, E., Guo, A. M., Gotlinger, K., Kornowski, R., Leshem-Lev, D., Lev, E., Porat, E., Snir, E., Thompson, C., Abraham, N. G., & Schwartzman, M. A. (2013). Elevated Level of Pro-Inflammatory Eicosanoids and EPC Dysfunction in Diabetic Patients With Cardiac Ischemia. Prostaglandins & Other Lipid Mediators, 100-101, 15-21. https://doi.org/10.1016/j.prostaglandins.2012.12.002